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MDPI, Genes, 4(3), p. 759-778, 2012

DOI: 10.3390/genes3040759

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Use of RNA Interference by In Utero Electroporation to Study Cortical Development: The Example of the Doublecortin Superfamily

Journal article published in 2012 by Orly Reiner ORCID, Anna Gorelik, Raanan Greenman
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The way we study cortical development has undergone a revolution in the last few years following the ability to use shRNA in the developing brain of the rodent embryo. The first gene to be knocked-down in the developing brain was doublecortin (Dcx). Here we will review knockdown experiments in the developing brain and compare them with knockout experiments, thus highlighting the advantages and disadvantages using the different systems. Our review will focus on experiments relating to the doublecortin superfamily of proteins.