Published in
Oxford University Press (OUP), European Heart Journal, 47(36), p. 3359-3367
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Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFRct: outcome and resource impacts study
,
Manesh R. Patel,
Bjarne L. Norgaard,
Robert A. Byrne ,
Nick Curzen,
Ian Purcell,
Matthias Gutberlet,
Gilles Rioufol,
Ulrich Hink,
Herwig Walter Schuchlenz,
Gudrun Feuchtner,
Martine Gilard,
Daniele Andreini
and other authors.
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Abstract
Aims In symptomatic patients with suspected coronary artery disease (CAD), computed tomographic angiography (CTA) improves patient selection for invasive coronary angiography (ICA) compared with functional testing. The impact of measuring fractional flow reserve by CTA (FFRCT) is unknown. Methods and results At 11 sites, 584 patients with new onset chest pain were prospectively assigned to receive either usual testing (n = 287) or CTA/FFRCT (n = 297). Test interpretation and care decisions were made by the clinical care team. The primary endpoint was the percentage of those with planned ICA in whom no significant obstructive CAD (no stenosis ≥50% by core laboratory quantitative analysis or invasive FFR