Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 10(10), p. 1097-1100, 2000
DOI: 10.1016/s0960-894x(00)00166-9
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First pharmacophoric hypothesis for 5-HT 7 antagonism
Journal article published in 2000 by
Marı́a L. López-Rodrı́guez 
,
Esther Porras,
Bellinda Benhamú,
José A. Ramos,
M. José Morcillo,
José L. Lavandera
,
Esther Porras,
Bellinda Benhamú,
José A. Ramos,
M. José Morcillo,
José L. Lavandera
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Abstract
In order to make the first contribution to the elucidation of essential structural features for 5-HT7 antagonism, a set of thirty 5-HT7 antagonists were selected from the literature. A pharmacophore model was built using Molecular Modeling studies with Catalyst program. The information contained in this model was validated with new synthesized compounds.