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Oxford University Press, Nucleic Acids Research, 7(20), p. 1599-1606, 1992

DOI: 10.1093/nar/20.7.1599

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The murineHox-2.4promoter contains a functional octamer motif

Journal article published in 1992 by Fried Zwartkruis ORCID, Truus Hoeijmakers, Jacqueline Deschamps, Frits Meijlink
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Like other HOX genes the murine Hox-2.4 gene is thought to be involved in regional specification along the antero-posterior axis. In addition it has been reported to have oncogenic potential. We studied expression Hox-2.4 in murine EC cells and determined the transcription start site. Studies of DNA-protein interactions in the promoter region showed that the Hox-2.4 promoter contains a CCAAT box and a perfect octamer motif, which is capable of binding Oct-factors. Cotransfection of Oct expression vectors influences the transcriptional activity of the promoter, suggesting that the Oct-gene family may be involved in regulating HOX genes.