Two clones of Norway spruce Picea abies (L.) Karst. (Gerardmer clone and Istebna clone) were subjected to an ozone-enriched atmosphere. The X-ray microanalysis of elements present in the guard cells showed a decrease in potassium for the Gerardmer clone along with a larger closing of guard cells and an increase in calcium contents; for the Istebna clone, ozone did not affect these contents. When a drought stress was applied, an increase in calcium content of guard cells of the Istebna clone was also found. However, the potassium content was smaller in this case for the two clones and could well be due to stomatal closure. When ozone and drought stress were applied together, the potassium content in the Istebna clone was not affected, but for the Gerardmer clone, ozone reduced the decrease in potassium content that occurred as drought stress developed. However, calcium (and manganese) content increased significantly when the Gerardmer clone was exposed to ozone. It seems likely that the Gerardmer clone is sensitive to ozone and when subjected to a drought stress this sensitivity is increased. For the Istebna clone, the resistance to ozone is unaffected by the drought stress treatment. The Istebna clone, however, seems sensitive to drought. These characteristic responses in the two different Norway spruce clones are probably due to genetic differences and may explain the contradictory observations in the response of the stomata during the simultaneous implementation of the complex stresses. Key words: Picea abies, guard cells, ozone, drought stress, X-ray microanalysis, elements.