Compared to conventional top-down photo-cleavage method, a facile bottom-up ink-combination method to in situ and rapidly achieve water wettability and adhesion transition, with a great contrast on the superamphiphobic TiO2 nanostructured film, is described. Moreover, such combination method is suitable for various kinds of superamphiphobic substrate. Oil-based ink covering or removing changes not only the topographical morphology but also surface chemical composition, and these resultant topographical morphology and composition engineering realize the site-selectively switchable wettability varying from superamphiphobicity to amphiphilicity, and water adhesion between sliding superamphiphobicity and sticky superamphiphobicity in micro-scale. Additionally, positive and negative micro-pattern can be achieved by taking advantage of the inherent photocatalytic property of TiO2 with the assistance of anti-UV light ink mask. Finally, the potential applications of the site-selectively sticky superamphiphobic surface were demonstrated. In a proof-of-concept study, the microdroplet manipulation (storage, moving, mixing, and transfer), specific gas sensing, wettability template for positive and negative ZnO patterning, and site-selective cell immobilization have been demonstrated. This study will give an important input to the field of advanced functional material surfaces with special wettability.