The emission of gases and aerosols due to volcanic activity may impact significantly atmospheric composition, cloud occurrence and properties, and the regional and global climate. While the effects of strong explosive (stratospheric) eruptions are relatively well known, limited information on the impacts of small to moderate volcanic activities, including passive degassing, is available. In this paper, the downwind impact of Mount Etna's sulfur emissions on the central Mediterranean is investigated on a statistical basis over the period 2000-2013 using: (a) daily sulfur dioxide emission rates measured near crater at Mount Etna with ground-based ultraviolet spectrophotometers, (b) Lagrangian trajec-tories and simulated plume dispersion obtained with the FLEXPART (FLEXible PARTicle dispersion) model, and (c) long-term observations of column SO 2 concentration and aerosolÅngströmaerosolÅngström exponent α at Lampedusa (35.5 • N, 12.6 • E). * Corresponding author, Phone number: 0033 (0)6 83 35 09 57. This statistical analysis has allowed, for the first time, the characterization of decadal impact of Mount Etna's sulfur emissions on the sulfur dioxide and the aerosol microphysical/optical properties in the central Mediterranean. On average , statistically significant higher SO 2 concentrations and smaller aerosol sizes are present when air masses from Mount Etna overpass Lampedusa. Despite being upwind of Lampedusa for only 5% of the time, Mount Etna is potentially responsible for up to 40% and 20% of the SO 2 and α extreme values (exceedances of a fixed threshold), respectively, at this location. The most important factor determining this perturbation is the prevailing dynamics, while the magnitude of the SO 2 emission rates from Mount Etna appears to be likely important only for relatively strong emissions. The observed perturbations to the aerosol size distribution are expected to produce a direct regional radiative effect in this area.