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Springer, Journal of Flow Chemistry, 3(4), p. 105-109, 2014

DOI: 10.1556/jfc-d-14-00005

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First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives. Further selective reduction of the ester formed to an aldehyde in flow is also described.