Superficial sediments from Cap de Creus to the Rhone Delta, in the Gulf of Lion, Northwestern Mediter-ranean Sea, including the mid-shelf mud belt and the continental slope were collected between 2005 and 2008 to assess the levels, main sources and distribution patterns of organochlorine pollutants. Discharges from the Rhone River are the main source for all these compounds around the area. The spatial distribu-tion of organochlorine pollutants was also related to their physicochemical properties and to sediment grain size and composition. The concentrations of polychlorobiphenyls (PCBs), dichlorodiphenyltrichloro-ethane (DDT) and its metabolites (DDD and DDE), and the chlorobenzenes (CBzs) – pentachlorobenzene (PeCB) and hexachlorobenzene (HCB) – decreased westwards along the mid-shelf mud belt. In contrast, hexachlorocyclohexane isomers (HCHs), namely lindane (c-HCH), followed another concentration pat-tern suggesting a different transport mode. The major concentrations of organochlorine compounds were observed off the Rhone River mouth, in the prodelta, where PCB, DDT and CBz concentrations reached 38, 29 and 8.3 ng g À1 , respectively. These average concentrations in the mid continental shelf were two to ten times lower than those found in a study performed about 20 years ago, albeit in almost all the sites the values of PCBs and DDTs still exceed the NOAA's Sediment Quality Guidelines. In contrast, the concentra-tions in the continental slope were nearly the same as 20 years ago, which may evidence that even most of these compounds were banned decades ago, their background concentrations associated to diffuse pol-lution have not decreased in the deep continental margin.