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Springer Nature [academic journals on nature.com], Pediatric Research, 3(66), p. 323-328, 2009

DOI: 10.1203/pdr.0b013e3181b1bbec

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Physiological partial aldosterone resistance in human newborns.

Journal article published in 2009 by Laetitia Martinerie, Eric Pussard, Laurence Foix-L'hélias, François Petit ORCID, Claudine Cosson, Pascal Boileau, Marc Lombès
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Abstract

In the neonatal period, the human kidney is characterized by an impaired ability to regulate water and sodium homeostasis, resembling partial aldosterone resistance. The aim of our study was to assess this hormonal insensitivity in newborn infants and to determine its relationship with neonatal sodium handling. We conducted a prospective study in 48 healthy newborns and their mothers. Aldosterone, renin, and electrolyte concentrations were measured in umbilical cords and in maternal plasma. Urinary aldosterone concentrations and sodium excretion were determined at urination within 24 h after birth. A significant difference was observed between aldosterone and renin levels in newborn infants compared with their mothers (817 +/- 73 versus 575 +/- 55 pg/mL and 79 +/- 10 versus 15 +/- 2 pg/mL, respectively, p