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Oxford University Press, Clinical Infectious Diseases, 9(59), p. 1322-1331, 2014

DOI: 10.1093/cid/ciu573

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Rapid Disease Progression in HIV-1 Subtype C-Infected South African Women

Journal article published in 2014 by Koleka Mlisana, Lise Werner, Nigel J. Garrett, Lyle R. McKinnon ORCID, Francois van Loggerenberg, Jo-Ann S. Passmore, Clive M. Gray, Lynn Morris, Carolyn Williamson, Salim Safurdeen Abdool Karim
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Abstract

CAPRISA, 2014. ; Background. Whereas human immunodeficiency virus (HIV) subtype B–infected individuals generally progress to AIDS within 8–10 years, limited data exist for other clades, especially from Africa. We investigated rates of HIV disease progression of clade C–infected South African women. Methods. Prospective seroincidence cohorts in KwaZulu-Natal were assessed for acute HIV infection monthly (n = 245) or every 3 months (n = 594) for up to 4 years. Rapid disease progression was defined as CD4 decline to