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Frontiers Media, Frontiers in Psychiatry, (4)

DOI: 10.3389/fpsyt.2013.00092

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Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis

Journal article published in 2013 by Susanna L. Fryer, Scott W. Woods, Kent A. Kiehl, Vince D. Calhoun, Godfrey D. Pearlson, Brian J. Roach, Judith M. Ford, Vinod H. Srihari, Thomas H. McGlashan, Daniel H. Mathalon ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: The default mode network (DMN) is a set of brain regions typically activated at rest and suppressed during extrinsic cognition. Schizophrenia has been associated with deficient DMN suppression, though the extent to which DMN dysfunction predates psychosis onset is unclear. This study examined DMN suppression during working memory (WM) performance in youth at clinical high-risk (CHR) for psychosis, early schizophrenia (ESZ) patients, and healthy controls (HC). We hypothesized that the DMN would show load-dependent suppression during WM retrieval in HC but not in ESZ, with CHR participants showing an intermediate pattern.