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Elsevier, Drug Discovery Today: Disease Mechanisms, 3-4(5), p. e285-e292

DOI: 10.1016/j.ddmec.2008.09.004

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The chemokine system as therapeutic target in cardiovascular disease

Journal article published in 2008 by Rory R. Koenen ORCID, Christian Weber, Philipp Von Hundelshausen
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The chemokine system is crucially involved in the progression of cardiovascular disease by orchestrating the influx of inflammatory cells into atherosclerotic lesions. This review highlights the currently established knowledge about the role of the chemokine system in plaque progression and the potential therapeutic approaches and available compounds currently inves-tigated for the treatment of atherosclerotic cardiovas-cular disease.