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Elsevier, Year Book of Pediatrics, (2012), p. 252-254

DOI: 10.1016/j.yped.2011.04.056

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Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

Journal article published in 2010 by Arjen M. Dondorp, L. Von Seidlein, Caterina I. Fanello, Ilse Ce E. Hendriksen, Ermelinda Gomes, Amir Seni, J. A. Stockman, Kajal D. Chhaganlal, Kalifa Bojang, Rasaq Olaosebikan, Nkechinyere Anunobi, Kathryn Maitland ORCID, Esther Kivaya, Tsiri Agbenyega, Samuel Blay Nguah and other authors.
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Abstract

BACKGROUND: Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compared parenteral treatment with either artesunate or quinine in African children with severe malaria. METHODS: This open-label, randomised trial was undertaken in 11 centres in nine African countries. Children (