We read with great interest, but no real surprise, the letter by Musial and Zwolinska published in a recent issue of your Journal [1]. These authors comment on their findings in dialysis patients suggesting a possible correlation between the levels of MMP-7 (matrilysin) and the severity of cardiovascular complications during end-stage kidney disease, and aptly discuss the characteristic of this particular metalloproteinase that may help explain such involvement [1]. The reason why this proposal is not too surprising, at least to us, is that a few years ago we studied (with microarrays) the genomic profile of primary cell cultures of native and regenerated (after balloon angioplasty) porcine coronary endothelial cells from the same hearts [2].