Published in
Public Library of Science, PLoS ONE, 2(6), p. e16652, 2011
DOI: 10.1371/journal.pone.0016652
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- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1
,
Anné Møller-Larsen,
Annette Bang Oturai,
Palle Villesen,
Bettina Hansen,
Kari K. Nissen,
Magdalena J. Laska,
Trine Skov Petersen,
Sandra Bonnesen,
Anne Hedemand,
Tingting Wu,
Xinjie Wang,
Xiuqing Zhang
and other authors.
Full text: Download
Abstract
We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.