Very severe cyclonic storm Nargis devastated Burma (Myanmar) in May 2008, caused tremendous damage and numerous fatalities, and became one of the 10 deadliest tropical cyclones (TCs) of all time. To increase the warning time in order to save lives and reduce economic damage, it is important to extend the lead time in the prediction of TCs like Nargis. As recent advances in high-resolution global models and supercomputing technology have shown the potential for improving TC track and intensity forecasts, the ability of a global mesoscale model to predict TC genesis in the Indian Ocean is examined in this study with the aim of improving simulations of TC climate. High-resolution global simulations with real data show that the initial formation and intensity variations of TC Nargis can be realistically predicted up to 5 days in advance. Preliminary analysis suggests that improved representations of the following environmental conditions and their hierarchical multiscale interactions were the key to achieving this lead time: (1) a westerly wind burst and equatorial trough, (2) an enhanced monsoon circulation with a zero wind shear line, (3) good upper-level outflow with anti-cyclonic wind shear between 200 and 850 hPa, and (4) low-level moisture convergence.