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BioMed Central, BMC Medicine, 1(7), 2009

DOI: 10.1186/1741-7015-7-34

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Identification of pediatric septic shock subclasses based on genome-wide expression profiling

Journal article published in 2009 by Hector R. Wong ORCID, Natalie Cvijanovich, Richard Lin, Geoffrey L. Allen, Neal J. Thomas, Douglas F. Willson, Robert J. Freishtat ORCID, Nick Anas, Keith Meyer, Paul A. Checchia, Marie Monaco, Kelli Odom, Kelli Odoms, Thomas P. Shanley
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Septic shock is a heterogeneous syndrome within which probably exist several biological subclasses. Discovery and identification of septic shock subclasses could provide the foundation for the design of more specifically targeted therapies. Herein we tested the hypothesis that pediatric septic shock subclasses can be discovered through genome-wide expression profiling. Methods Genome-wide expression profiling was conducted using whole blood-derived RNA from 98 children with septic shock, followed by a series of bioinformatic approaches targeted at subclass discovery and characterization. Results Three putative subclasses (subclasses A, B, and C) were initially identified based on an empiric, discovery-oriented expression filter and unsupervised hierarchical clustering. Statistical comparison of the three putative subclasses (analysis of variance, Bonferonni correction, P