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American Chemical Society, Nano Letters, 8(15), p. 5178-5184, 2015

DOI: 10.1021/acs.nanolett.5b01400

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Size-Tunable Organic Nanodot Arrays: A Versatile Platform for Manipulating and Imaging Cells

Journal article published in 2015 by Fuwei Pi, Pierre Dillard, Ranime Alameddine, Emmanuelle Benard, Astrid Wahl, Igor Ozerov ORCID, Anne Charrier, Laurent Limozin, Kheya Sengupta ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Arrays of protein nano-dots with dot-size tuned independently of spacing (e.g. ~100 to 600 nm diameter for 900 nm spacing) are fabricated. The mechanism of size control is demonstrated, by numerical simulations, to arise from shadow effects during deposition of a sacrificial metal mask. We functionalize the nano-dots with antibodies and embed them in a polymer-cushion or in lipid-bilayers, or transfer them to soft elastomers. Their ability to influence local membrane composition and cell architecture is demonstrated in T-lymphocytes, using reflection interference contrast and total internal reflection fluorescence microscopy.