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American Physical Society, Physical Review Letters, 20(95), 2005

DOI: 10.1103/physrevlett.95.208103

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Finding the Center Reliably: Robust Patterns of Developmental Gene Expression

Journal article published in 2005 by Martin Howard ORCID, Pieter Rein ten Wolde
This paper is available in a repository.
This paper is available in a repository.

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Postprint: archiving allowed
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Data provided by SHERPA/RoMEO

Abstract

We investigate a mechanism for the robust identification of the center of a developing biological system. We assume the existence of two morphogen gradients, an activator emanating from the anterior, and a corepressor from the posterior. The corepressor inhibits the action of the activator in switching on target genes. We apply this system to Drosophila embryos, where we predict the existence of a hitherto undetected posterior corepressor. Using mathematical modeling, we show that a symmetric activator-corepressor model can quantitatively explain the precise midembryo expression boundary of the hunchback gene, and the scaling of this pattern with embryo size.