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Nature Research, Scientific Reports, 1(5), 2015

DOI: 10.1038/srep16248

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Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody

Journal article published in 2015 by Nimesh Gupta ORCID, Mélissanne de Wispelaere, Maxime Lecerf, Manjula Kalia, Tobias Scheel, Sudhanshu Vrati, Claudia Berek, Srinivas V. Kaveri, Philippe Desprès, Sébastien Lacroix-Desmazes, Jordan D. Dimitrov
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractGeographical expansion and re-emerging new genotypes of the Japanese encephalitis virus (JEV) require the development of novel therapeutic approaches. Here, we studied a non-conventional approach for antibody therapy and show that, upon exposure to heme, a fraction of natural human immunoglobulins acquires high-affinity reactivity with the antigenic domain-III of JEV E glycoprotein. These JEV-reactive antibodies exhibited neutralizing activity against recently dominant JEV genotypes. This study opens new therapeutic options for Japanese encephalitis.