Published in
American Chemical Society, ACS Medicinal Chemistry Letters, 1(4), p. 75-78, 2012
DOI: 10.1021/ml300284b
Links
- ORCID
- ORCID
- American Chemical Society
- ORCID
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
Tuning RNA interference by enhancing siRNA/PAZ recognition
Journal article published in 2012 by
Maria Gaglione,
Nicoletta Potenza,
Giovanni Di Fabio,
Valeria Romanucci 
,
Nicola Mosca,
Aniello Russo ,
Ettore Novellino,
Sandro Cosconati ,
Anna Messere
,
Nicola Mosca,
Aniello Russo ,
Ettore Novellino,
Sandro Cosconati ,
Anna Messere
This paper is available in a repository.
Full text: Download
Preprint: archiving allowed
- Must obtain written permission from Editor
- Must not violate ACS ethical Guidelines
Postprint:
archiving restricted
- Must obtain written permission from Editor
- Must not violate ACS ethical Guidelines
Published version:
archiving forbidden
Data provided by 
Abstract
Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theoretical data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ.