Solids composed of TiO2 nano‐crystallites (10–40 wt %) dispersed in an SBA‐15 matrix were synthesised and used as hydrodesulfurisation (HDS) active‐phase supports. Well‐dispersed polymolybdate species were detected by Raman spectroscopy on all the CoMo‐based oxidic precursors. Undesirable bulk CoMoO4 mixed oxide was also detected on the surface of low‐TiO2‐content materials, which suggests the enhancement of the Mo oxidic species dispersion as a result of the presence of TiO2. After activation under H2/H2S, the obtained catalysts were tested in the HDS of thiophene. An optimum conversion was observed for the catalyst supported on the solid that contained 20 wt % TiO2, which outperformed the homologous samples supported on TiO2 and SBA‐15. This clearly highlights the beneficial effect of using such nano‐TiO2‐SBA‐15 composite supports, in which SBA‐15 confers adequate textural properties to the system, and the active phase benefits from the dispersive effect of TiO2.