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Nature Research, Nature Biotechnology, 12(29), p. 1117-1119, 2011

DOI: 10.1038/nbt.2052

Nature Research, Nature Biotechnology, 1(30), p. 112-112, 2012

DOI: 10.1038/nbt0112-112b

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Erratum: Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

Journal article published in 2011 by Kitai Kim, Rui Zhao, Akiko Doi, Kitwa Ng, Juli Unternaehrer, Patrick Cahan, Huo Hongguang, Yuin-Han Loh ORCID, Martin J. Aryee, M. William Lensch, M. William Lensch, Hu Li, James J. Collins, Andrew P. Feinberg, George Q. Daley
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We compared bona fide human induced pluripotent stem cells (iPSCs) derived from umbilical cord blood (CB) cells and neonatal keratinocytes (K). As a consequence of both incomplete erasure of tissue-specific methylation and aberrant de novo methylation, CB-iPSCs and K-iPSCs were distinct in genome-wide DNA methylation profiles and differentiation potential. Extended passage of some iPSC clones in culture did not improve their epigenetic resemblance to embryonic stem cells, implying that some human iPSCs retain a residual 'epigenetic memory' of their tissue of origin.