Published in
American Society of Hematology, Blood, 15(125), p. 2370-2380, 2015
DOI: 10.1182/blood-2014-09-602565
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The cellular origin and malignant transformation of Waldenstrom macroglobulinemia
Journal article published in 2015 by
Alfonso García de Coca,
Bruno Paiva 
,
Maria-Belen Vidriales ,
Luis A. Corchete,
Corchete La,
Vidriales Mb,
Ramón García-Sanz,
Jose J. Perez,
Perez Jj,
Irene Aires-Mejia,
Maria-Luz Sanchez,
Paloma Barcena,
Sanchez Ml,
Diego Alignani,
Cristina Jimenez
and other authors.
,
Maria-Belen Vidriales ,
Luis A. Corchete,
Corchete La,
Vidriales Mb,
Ramón García-Sanz,
Jose J. Perez,
Perez Jj,
Irene Aires-Mejia,
Maria-Luz Sanchez,
Paloma Barcena,
Sanchez Ml,
Diego Alignani,
Cristina Jimenez
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Benign (ie, IgM MGUS and smoldering WM) clonal B cells already harbor the phenotypic and molecular signatures of the malignant WM clone. Multistep transformation from benign (ie, IgM MGUS and smoldering WM) to malignant WM may require specific copy number abnormalities.