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Springer (part of Springer Nature), Marine Biotechnology, 4(14), p. 396-401

DOI: 10.1007/s10126-012-9463-2

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Bioconversion of Iodoacetophenones by Marine Fungi

Journal article published in 2012 by Lenilson C. Rocha, Rodrigo F. Luiz, Isac G. Rosset, Cristiano Raminelli, Mirna H. R. Seleghim, Lara Durães Sette ORCID, André L. M. Porto
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Nine marine fungi (Aspergillus sclerotiorum CBMAI 849, Aspergillus sydowii Ce19, Beauveria felina CBMAI 738, Mucor racemosus CBMAI 847, Penicillium citrinum CBMAI 1186, Penicillium miczynskii Ce16, P. miczynskii Gc5, Penicillium oxalicum CBMAI 1185, and Trichoderma sp. Gc1) catalyzed the asymmetric bioconversion of iodoacetophenones 1-3 to corresponding iodophenylethanols 6-8. All the marine fungi produced exclusively (S)-ortho-iodophenylethanol 6 and (S)-meta-iodophenylethanol 7 in accordance to the Prelog rule. B. felina CBMAI 738, P. miczynskii Gc5, P. oxalicum CBMAI 1185, and Trichoderma sp. Gc1 produced (R)-para-iodophenylethanol 8 as product anti-Prelog. The bioconversion of para-iodoacetophenone 3 with whole cells of P. oxalicum CBMAI 1185 showed competitive reduction-oxidation reactions.