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Karger Publishers, Dementia and Geriatric Cognitive Disorders, 3-4(35), p. 208-218, 2013

DOI: 10.1159/000346389

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Distinguishing Subtypes in Primary Progressive Aphasia: Application of the Sydney Language Battery

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

<b><i>Background/Aims:</i></b> Primary progressive aphasia (PPA) comprises three main subtypes, varying in clinical features, patterns of brain atrophy, and underlying pathology. Differentiation of these variants is important for treatment and planning; however, simple, effective cognitive tests to aid diagnosis are lacking. This study introduces a new language battery - the SYDBAT (Sydney Language Battery) - to assist clinicians. <b><i>Methods:</i></b> Fifty-seven PPA patients and 54 age- and education-matched healthy controls were compared on naming, repetition, word comprehension, and semantic association subtests. <b><i>Results:</i></b> Significant group differences were found for all tasks, reflecting different language profiles for each group. Using discriminative function analysis, 80% of PPA cases were correctly classified from three SYDBAT scores, from which a simple diagnostic algorithm was defined. <b><i>Conclusion:</i></b> The SYDBAT is a fast and simple tool which provides a valuable adjunct to clinicians diagnosing PPA.