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BioMed Central, Arthritis Research and Therapy, 3(15), p. 214

DOI: 10.1186/ar4228

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Microbes, the gut and ankylosing spondylitis

Journal article published in 2013 by Mary-Ellen Costello, Dirk Elewaut ORCID, Tony J. Kenna, Matthew A. Brown
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

It is increasingly clear that the interaction between host and microbiome profoundly affects health. There are 10 times more bacteria in and on our bodies than the total of our own cells, and the human intestine contains approximately 100 trillion bacteria. Interrogation of microbial communities by using classic microbiology techniques offers a very restricted view of these communities, allowing us to see only what we can grow in isolation. However, recent advances in sequencing technologies have greatly facilitated systematic and comprehensive studies of the role of the microbiome in human health and disease. Comprehensive understanding of our microbiome will enhance understanding of disease pathogenesis, which in turn may lead to rationally targeted therapy for a number of conditions, including autoimmunity.