Mixed numerical–experimental methods are increasingly used in various disciplines in materials science, recently also in wood micromechanics. Having a relatively irregular microstructure, direct interpretation of mechanical tests is not always possible since structurally specific properties are quantified rather than general material properties. The advent of combined numerical–experimental methods unlocks possibilities for a more accurate experimental characterization. A number of examples of mixed methods pertaining to both emerging experimental techniques and physical phenomena are presented: nano-indentation, moisture transport, digital-image correlation, dimensional instability and fracture of wood-based materials. Successful examples from other classes of materials are also presented, in an attempt to provide some ideas potentially useful in wood mechanics. Some general pit-falls in parameter estimation from experimental results are also outlined.