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Society of Photo-optical Instrumentation Engineers, Journal of Biomedical Optics, 11(19), p. 119801

DOI: 10.1117/1.jbo.19.11.119801

Society of Photo-optical Instrumentation Engineers, Journal of Biomedical Optics, 11(19), p. 110501

DOI: 10.1117/1.jbo.19.11.110501

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Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography

Journal article published in 2014 by Dolonchampa Maji, Metasebya Solomon, Annie Nguyen, Richard A. Pierce, Pamela K. Woodard, Walter J. Akers ORCID, Samuel Achilefu, Joseph P. Culver, Dana R. Abendschein, Monica Shokeen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Insights into the etiology of stroke and myocardial infarction suggest that rupture of unstable atherosclerotic plaque is the precipitating event. Clinicians lack tools to detect lesion instability early enough to intervene, and are often left to manage patients empirically, or worse, after plaque rupture. Noninvasive imaging of the molecular events signaling prerupture plaque progression has the potential to reduce the morbidity and mortality associated with myocardial infarction and stroke by allowing early intervention. Here, we demonstrate proof-of-principle in vivo molecular imaging of C-type natriuretic peptide receptor in focal atherosclerotic lesions in the femoral arteries of New Zealand white rabbits using a custom built fiber-based, fluorescence molecular tomography (FMT) system. Longitudinal imaging showed changes in the fluorescence signal intensity as the plaque progressed in the air-desiccated vessel compared to the uninjured vessel, which was validated by ex vivo tissue studies. In summary, we demonstrate the potential of FMT for noninvasive detection of molecular events leading to unstable lesions heralding plaque rupture.