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Springer Nature [academic journals on nature.com], Cell Research, 12(24), p. 1383-1384, 2014

DOI: 10.1038/cr.2014.114

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Mixed messages: Re-initiation factors regulate translation of animal mRNAs

Journal article published in 2014 by Benedikt Obermayer ORCID, Nikolaus Rajewsky
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

When ribosomes encounter upstream open reading frames (uORFs) during scanning of the 5' untranslated region (5' UTR), translation of the downstream ORF requires re-initiation. In a recent paper in Nature, Schleich et al. describe metazoan factors which specifically promote re-initiation.