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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 10(59), p. 6638-6641, 2015

DOI: 10.1128/aac.01136-15

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Purification Methodology for Viable and Infective Plasmodium vivax Gametocytes That Is Compatible with Transmission-Blocking Assays

Journal article published in 2015 by Omaira Vera, Paula Brelas de Brito, Paula Brelaz, Letusa Albrecht, Keillen Monick Martins-Campos, Keillen Monick, Paulo Filemon Paolucci Pimenta, Wuelton M. Monteiro, Marcus V. G. Lacerda, Stefanie C. P. Lopes ORCID, Fabio T. M. Costa
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Significant progress toward the control of malaria has been achieved, especially regarding Plasmodium falciparum infections. However, the unique biology of Plasmodium vivax hampers current control strategies. The early appearance of P. vivax gametocytes in the peripheral blood and the impossibility of culturing this parasite are major drawbacks. Using blood samples from 40 P. vivax -infected patients, we describe here a methodology to purify viable gametocytes and further infect anophelines. This method opens new avenues to validate transmission-blocking strategies.