Published in

Elsevier, Parkinsonism & Related Disorders, (22), p. S123-S126, 2016

DOI: 10.1016/j.parkreldis.2015.09.028

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Adaptive Deep Brain Stimulation in Parkinson’s disease

Journal article published in 2015 by M. Beudel ORCID, Peter Brown ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Although Deep Brain Stimulation (DBS) is an established treatment for Parkinson's disease (PD), there are still limitations in terms of effectivity, side-effects and battery consumption. One of the reasons for this may be that not only pathological but also physiological neural activity can be suppressed whilst stimulating. For this reason, adaptive DBS (aDBS), where stimulation is applied according to the level of pathological activity, might be advantageous. Initial studies of aDBS demonstrate effectiveness in PD, but there are still many questions to be answered before aDBS can be applied clinically. Here we discuss the feedback signals and stimulation algorithms involved in adaptive stimulation in PD and sketch a potential road-map towards clinical application.