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Royal Society of Chemistry, Chemical Science, 2(4), p. 858-862

DOI: 10.1039/c2sc21499g

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Proof of principle for a molecular 1 : 2 demultiplexer to function as an autonomously switching theranostic device

Journal article published in 2013 by Sundus Erbas-Cakmak, O. Altan Bozdemir, Yusuf Cakmak, Engin U. Akkaya ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Guided by the digital design concepts, we synthesized a two-module molecular demultiplexer (DEMUX) where the output is switched between emission at near IR, and cytotoxic singlet oxygen, with light at 625 nm as the input (I), and acid as the control (c). In the neutral form, the compound fluoresces brightly under excitation at 625 nm, however, acid addition moves the absorption bands of the two modules in opposite directions, resulting in an effective reversal of excitation energy transfer direction, with a concomitant upsurge of singlet oxygen generation and decrease in emission intensity.