Published in
Oxford University Press, American Journal of Hypertension, 4(25), p. 451-457, 2012
DOI: 10.1038/ajh.2011.257
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The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level
,
Giovanni Boschetti,
Anna Bascelli,
Mario Saugo,
Giuseppe Guglielmi,
Sandro Caffi,
Giulio Rigoni,
Nunzia Giordano,
Carla Grasselli,
Bortolo Martini,
Alberto Mazza,
Fabia De Lazzari,
F. D. Lazzari,
Paolo Palatini
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Abstract
BACKGROUND The role of C825T polymorphism of the candidate GNB3 gene in predicting cerebrovascular outcome has been poorly explored in longitudinal setting at a population level. METHODS In an epidemiological setting, 1,678 men and women from general population were genotyped for C825T polymorphism of GNB3 gene and follow-up for 10 years to detect nonfatal and fatal cerebrovascular events (CE). Established cerebrovascular risk factors were used to adjust the multivariate Cox analysis for confounders. RESULTS Seventy-three nonfatal and 30 fatal CE were recorded. Incidence of CE was higher in TT than in C-carriers (fatal: 2.6 vs. 1.7%, P