Published in

Frontiers Media, Frontiers in Immunology, (3)

DOI: 10.3389/fimmu.2012.00363

Links

Tools

Export citation

Search in Google Scholar

Trypanosoma cruzi extracellular amastigotes and host cell signaling: More pieces to the puzzle

Journal article published in 2012 by Éden R. Ferreira, Alexis Bonfim-Melo ORCID, Renato A. Mortara ORCID, Diana Bahia
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Among the different infective stages that Trypanosoma cruzi employs to invade cells, extracellular amastigotes (EAs) have recently gained attention by our group. This is true primarily because these amastigotes are able to infect cultured cells and animals, establishing a sustainable infective cycle. EAs are thus an excellent means of adaptation and survival for T. cruzi, whose different infective stages each utilize unique mechanisms for attachment and penetration. Here we discuss some features of host cell invasion by EAs and the associated host cell signaling events that occur as part of the process.