The present study explored the biometeorological conditions of mountainous communities of Nafpaktia (Municipality of Apodotia, Prefecture of Aitoloakarnania), a region without commercial, industrial or other activities, combining with noticeable tourist potential, in west continental Greece, in comparison to the biometeorological conditions of Athens, a metropolitan urban center, in south- east continental Greece. Air temperature and humidity data were used for the calculation of a widely used biometeorological index, thermohygrometric index from which biometeorological conditions were evaluated. Results showed that mountainous communities of Nafpaktia provided clearly improved biometeorological conditions in comparison to those of Athens. Therefore, the previous communities should be further supported as a reliable alternative tourist destination for recreation and health improvement.