Crystallization fouling experiments were performed in a channel for a cross flow of hot saturated sodium sulphate (Na2SO4) solution over a pipe containing cold water. The heat transfer coefficient and fouling thermal resistance were determined from measurements of local surface temperature and the thickness of the crystalline fouling layer. A systematic assessment of the asymptotic variation of these parameters with time was obtained for a range of hot salt solution Reynolds number based on pipe diameter (RehD) of 165–485, salt solution bulk temperature of 30 °C–50 °C, and cold water (at 5 °C) Reynolds number in the pipe (Rec) of 7500–25000. It was found that the temperature of the salt solution has a large effect on the fouling rate. Increasing the pipe surface temperature decreases the crystallization fouling rate. Increasing the hot solution Reynolds number, via the velocity, decreases the fouling thermal resistance, while increasing the cold water Reynolds number, via the velocity, decreases the fouling thermal resistance, but at the same time it increases the fouling layer thickness. The crystallization process that applies here was found to be under activation control (i.e. chemical kinetic control) so that the mass transport of salt plays only a minor role.