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Wiley, Angewandte Chemie, 24(126), p. 6363-6366, 2014

DOI: 10.1002/ange.201402440

Wiley, Angewandte Chemie International Edition, 24(53), p. 6249-6252, 2014

DOI: 10.1002/anie.201402440

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Synthesis, Discovery, and Quantitation of Dihomo-Isofurans: Biomarkers for In Vivo Adrenic Acid Peroxidation.

Journal article published in 2014 by Aurélien de La Torre ORCID, Yiu Yiu Lee, Yiu Lee, Camille Oger, Per Torp Sangild, Thierry Durand, Jetty Chung-Yung Lee, Jetty Chung‐Yung Lee, Jean-Marie Galano
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.