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Wiley, Angewandte Chemie, 4(126), p. 1017-1020

DOI: 10.1002/ange.201308063

Wiley, Angewandte Chemie International Edition, 4(53), p. 999-1002

DOI: 10.1002/anie.201308063

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Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive π-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation.