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AcademicPres, Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology, 1(72)

DOI: 10.15835/buasvmcn-fst:11138

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Evaluation of Antiproliferative Potential of Cerium Oxide Nanoparticles on HeLa Human Cervical Tumor Cell

Journal article published in 2015 by Zoriţa Diaconeasa, Lucian Barbu Tudoran, Lucian Barbu-Tudoran, Cristina Coman, Loredana Leopold, Amalia Mesaroş, Oana Pop, Dumitriţa Rugină ORCID, Carmen Socaciu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cerium oxide nanoparticles (CeO2 nanoparticles) as nanomaterials have promising biomedical applications. In this paper, the cytotoxicity induced by CONPs human cervical tumor cells was investigated. Cerium oxide nanoparticles were synthesized using the precipitation method. The nanoparticles were found to inhibit the proliferation of HeLa human cervical tumor cells in a dose dependent manner but did not showed to be cytotoxic as analyzed by MTT assay. The administrated treatment decreased the HeLa cell viability cells from 100% to 65% at the dose of 100 μg/mL.