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Wiley, Angewandte Chemie International Edition, 22(47), p. 4110-4113, 2008

DOI: 10.1002/anie.200800726

Wiley, Angewandte Chemie, 22(120), p. 4178-4181, 2008

DOI: 10.1002/ange.200800726

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Binding of Aminoglycoside Antibiotics to the Duplex Form of the HIV-1 Genomic RNA Dimerization Initiation Site

Journal article published in 2008 by Séverine Freisz, Kathrin Lang ORCID, Ronald Micura, Philippe Dumas, Eric Ennifar
This paper is available in a repository.
This paper is available in a repository.

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Abstract

(Figure Presented) Targeting HIV RNA: High-resolution X-ray structures of the HIV-1 genomic RNA dimerization initiation site (DIS) extended duplex bound to several aminoglycoside antibiotics have been obtained (see ribostamycin complex as an example). They show the feasibility of targeting viral RNA with small drugs, and open up the possibility of structure-based rational drug design aimed against viral replication.