LA-ICP-MS U–Pb zircon dating reveals that the Phu Kham adakites in the Truong Son Belt were emplaced during the Late Carboniferous (ca. 306 to 304 Ma), whereas the Puthep 1 (PUT 1) adakites in the Loei Fold Belt were formed during the Middle Triassic (ca. 244 to 241 Ma). These rock formation ages are largely coeval to Re–Os molybdenite ages (Phu Kham: ca. 304 Ma; PUT 1: ca. 246 Ma), suggesting close temporal links between adakite formation and copper–gold mineralization. New geochemical results show that the Phu Kham and PUT 1 adakites are characterized by low HREE and Y contents, but elevated LREE, Sr, Sr/Y, and La/Yb values. In addition, the two adakites have relatively high 143Nd/144Nd ratios (0.512648 to 0.512719), Mg# (Phu Kham: 37–68; PUT 1: 40–65), and Cr and Ni contents. These results are best interpreted as representing slab melts that have interacted with supra-subduction zone mantle wedge during ascent. Tectonically, the Phu Kham and PUT 1 adakites were most likely formed during the initiation of subduction of the Ailaoshan–Song Ma and the Main Paleo-Tethys ocean plates respectively. Close temporal relations between the adakite formation and the copper–gold mineralization suggest strong genetic links between the two in the mainland SE Asia region.