Published in
Wiley, Angewandte Chemie International Edition, 23(41), p. 4529-4532, 2002
DOI: 10.1002/1521-3773(20021202)41:23<4529::aid-anie4529>3.0.co;2-2
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Mechanistic Studies of HPP Epoxidase: Configuration of the Substrate Governs Its Enzymatic Fate
Journal article published in 2002 by
Zongbao Zhao 
,
Pinghua Liu,
Kazuo Murakami,
Tomohisa Kuzuyama,
Haruo Seto,
Hung-Wen Liu
,
Pinghua Liu,
Kazuo Murakami,
Tomohisa Kuzuyama,
Haruo Seto,
Hung-Wen Liu
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Abstract
The regiospecificity of the initial H-atom abstraction may explain the fact that HPP epoxidase, a non-heme iron-containing enzyme, catalyzes not only the conversion of (S)-HPP ((S)-1) to fosfomycin (2), but also the oxidation of the 1R enantiomer, which leads exclusively to 3 with nearly equal efficiency.