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American Chemical Society, Journal of the American Chemical Society, 24(129), p. 7484-7485, 2007

DOI: 10.1021/ja070497d

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Single-Molecule Conformational Analysis of G-Quadruplex Formation in the Promoter DNA Duplex of the Proto-Oncogene C-Kit

Journal article published in 2007 by Pravin S. Shirude, Burak Okumus, Liming Ying ORCID, Taekjip Ha ORCID, Shankar Balasubramanian
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This paper is available in a repository.

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Abstract

Herein we report on the single-molecule analysis of a conserved DNA quadruplex element found in the transcriptional activation site of the promoter of the proto- oncogene c-kit. We demonstrate that the c-kit quadruplex motif is able to fold into nonduplex states within a natural extended DNA duplex. There are apparent differences in putative quadruplex structures, and the K+ dependence on quadruplex formation, that appear to result when studying this quadruplex motif in natural duplex, as opposed to the single-stranded form.