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CLINICAL CASES IN MINERAL AND BONE METABOLISM

DOI: 10.11138/ccmbm/2013.10.1.034

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The effects on bone cells of metal ions released from orthopaedic implants. A review

Journal article published in 2013 by Davide Pagani, Valerio Sansone ORCID, Marco Melato
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The increasing use of orthopedic implants and, in particular, of hip and knee joint replacements for young and active patients, has stimulated interest and concern regarding the chronic, long-term effects of the materials used. This review focuses on the current knowledge of the adverse biologic reactions to metal particles released from orthopaedic implants in vivo and in vitro. More specifically, the purpose of this article is to provide an overview of the current literature about the adverse effects of metal particles on bone cells and peri-implant bone.