Cell Press, Trends in Biochemical Sciences, 10(25), p. 469-474
DOI: 10.1016/s0968-0004(00)01632-7
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Progress on determining the function of the breast and ovarian cancer susceptibility gene BRCA1 suggests it might be involved in two fundamental cellular processes: DNA repair and transcriptional regulation. Recent developments indicate that BRCA1 is a multifunctional protein, and disruption of its transcriptional activity could be crucial for tumor development.