Published in

Oxford University Press, Carcinogenesis: Integrative Cancer Research, Suppl 1(36), p. S2-S18, 2015

DOI: 10.1093/carcin/bgv028

Links

Tools

Export citation

Search in Google Scholar

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Journal article published in 2015 by Rita Nahta, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Rafaela Andrade-Vieira, Sarah N. Bay, Dustin G. Brown, Gloria M. Calaf, Robert C. Castellino, Karine A. Cohen Solal, Annamaria Colacci, Nichola Cruickshanks, Paul Dent, Riccardo Di Fiore, Stefano Forte ORCID and other authors.
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.