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BioMed Central, Journal of Cardiovascular Magnetic Resonance, 1(17), 2015

DOI: 10.1186/s12968-015-0125-1

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Measurement of myocardial blood flow by cardiovascular magnetic resonance perfusion: Comparison of distributed parameter and Fermi models with single and dual bolus

Journal article published in 2015 by Giorgos Papanastasiou ORCID, Michelle C. Williams, Lucy E. Kershaw, Marc R. Dweck, Shirjel Alam, Saeed Mirsadraee, Martin Connell, Calum Gray, Tom MacGillivray, David E. Newby, Scott Ik Semple
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Mathematical modeling of cardiovascular magnetic resonance perfusion data allows absolute quantification of myocardial blood flow. Saturation of left ventricle signal during standard contrast administration can compromise the input function used when applying these models. This saturation effect is evident during application of standard Fermi models in single bolus perfusion data. Dual bolus injection protocols have been suggested to eliminate saturation but are much less practical in the clinical setting. The distributed parameter model can also be used for absolute quantification but has not been applied in patients with coronary artery disease. We assessed whether distributed parameter modeling might be less dependent on arterial input function saturation than Fermi modeling in healthy volunteers. We validated the accuracy of each model in detecting reduced myocardial blood flow in stenotic vessels versus gold-standard invasive methods.