Published in
Elsevier, Tetrahedron Letters, 31(43), p. 5483-5486
DOI: 10.1016/s0040-4039(02)01034-1
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A convenient synthesis of the novel carboranyl-substituted tetrahydroisoquinolines: Application to the biologically active agent for BNCT
Journal article published in 2002 by
Jong-Dae Lee,
Chai-Ho Lee,
Hiroyuki Nakamura 
,
Jaejung Ko,
Sang Ook Kang
,
Jaejung Ko,
Sang Ook Kang
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Abstract
A convenient method for o-carborane-substituted tetrahydroisoquinolines (THIQ) is described; in particular, compound 8c accumulates in B-16 melanoma cells with a significantly high level although its cytotoxicity is significantly low.